Nobel Prize in Chemistry

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    In News

    • Recently, the Nobel Prize in chemistry for 2022 was awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless.
      • The three have been awarded for their work in ‘click chemistry’.

    Click Chemistry

    • Click chemistry is utilized in the development of pharmaceuticals, for mapping DNA and creating materials that are more fit for purpose. 
      • The term “click chemistry” is used to describe reactions that are fast, high-yielding and clean, meaning that they do not produce a lot of unwanted side-products.

    Significance

    • It helps to develop “bioorthogonal” reactions that operate safely inside living organisms without disrupting their biochemistry. Using bioorthogonal reactions, researchers have improved the targeting of cancer pharmaceuticals.
    • The breakthrough allowed scientists to track the movement of biomolecules in cells and so tease apart the complex workings of life.
    • Replicating reactions that involve bonds between carbon atoms is expensive and often leads to side reactions and loss of material.
    • In click chemistry, instead of trying to make carbon atoms react with each other, it focuses on using smaller molecules that already have a complete carbon frame.

    Source:TH