{"id":51153,"date":"2025-08-12T20:38:58","date_gmt":"2025-08-12T15:08:58","guid":{"rendered":"https:\/\/www.nextias.com\/ca\/?p=51153"},"modified":"2025-08-13T00:12:29","modified_gmt":"2025-08-12T18:42:29","slug":"landmark-study-offers-new-insights-into-what-protects-against-dengue","status":"publish","type":"post","link":"https:\/\/www.nextias.com\/ca\/current-affairs\/12-08-2025\/landmark-study-offers-new-insights-into-what-protects-against-dengue","title":{"rendered":"Landmark Study Offers New Insights into What Protects Against Dengue"},"content":{"rendered":"\n<p><strong>Syllabus: GS2\/Health<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Context<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A novel study has revealed important insights into <strong>developing strong immunity against DENV, which is otherwise quite complex.<\/strong><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>About<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Researchers from the US and Philippines have identified specific antibodies, known as <strong>envelope dimer epitope (EDE)-like antibodies<\/strong>, as the key for building broad, <strong>cross-serotype immunity<\/strong> following natural infection or vaccination.<\/li>\n\n\n\n<li>The findings represent a<strong> significant step<\/strong> forward in understanding dengue immunity and could lead to more effective therapeutics.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>About Dengue<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dengue is a<strong> mosquito-borne viral disease<\/strong> caused by the <strong>Dengue virus (DENV)<\/strong>, which has <strong>four serotypes <\/strong>(DENV-1, DENV-2, DENV-3, and DENV-4).\n<ul class=\"wp-block-list\">\n<li>It is transmitted primarily by the <strong>Aedes aegypti mosquito.<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Spread:<\/strong> The virus <strong>does not<\/strong><strong>spread person-to-person directly.<\/strong>\n<ul class=\"wp-block-list\">\n<li>A mosquito becomes infected by biting a person already infected with the virus, and then can <strong>transmit the virus to another person through a subsequent bite.<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Symptoms: <\/strong>Fever, severe headache, muscle and joint pains, nausea and vomiting, pain behind the eyes, and rashes.\n<ul class=\"wp-block-list\">\n<li>In severe cases, the infection can lead to internal bleeding, and if not managed properly, even death.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img data-dominant-color=\"e3eaea\" data-has-transparency=\"false\" loading=\"lazy\" decoding=\"async\" width=\"442\" height=\"502\" src=\"https:\/\/wp-images.nextias.com\/cdn-cgi\/image\/format=auto\/ca\/uploads\/2025\/08\/Landmark-Study-Offers-New-Insights-into-What-Protects-Against-Dengue.webp\" alt=\"Landmark-Study-Offers-New-Insights-into-What-Protects-Against-Dengue\" class=\"not-transparent wp-image-51154\" style=\"--dominant-color: #e3eaea; width:372px;height:auto\" srcset=\"https:\/\/wp-images.nextias.com\/cdn-cgi\/image\/format=auto\/ca\/uploads\/2025\/08\/Landmark-Study-Offers-New-Insights-into-What-Protects-Against-Dengue.webp 442w, https:\/\/wp-images.nextias.com\/cdn-cgi\/image\/format=auto\/ca\/uploads\/2025\/08\/Landmark-Study-Offers-New-Insights-into-What-Protects-Against-Dengue-264x300.webp 264w\" sizes=\"auto, (max-width: 442px) 100vw, 442px\" \/><\/figure>\n<\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Treatment:<\/strong> There is no specific treatment for dengue. Early detection of disease progression with proper medical care lowers fatality rates of severe dengue to below 1%.<\/li>\n\n\n\n<li><strong>Vaccine:<\/strong> Dengvaxia (CYD-TDV) \u2013 approved in some countries, recommended for individuals aged 9-16 with a history of dengue infection.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Dengue &amp; Vaccine Challenges<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Global burden:<\/strong> It is the<strong> <\/strong>most common vector-borne viral disease; half the world\u2019s population is at risk, especially in Southeast Asia, Africa, Americas.\n<ul class=\"wp-block-list\">\n<li><strong>Dengue fever <\/strong>is <strong>one of the top 10 threats<\/strong> to global health, according to the World Health Organisation (WHO).<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Dengue in India: <\/strong>India accounts for a large fraction of global dengue cases; 2.3 lakh cases and 297 deaths were reported in 2024.<\/li>\n\n\n\n<li><strong>Vaccine challenge: <\/strong>Primary immunity after first infection can worsen disease on second infection with different serotypes.\n<ul class=\"wp-block-list\">\n<li>Severe dengue cases (requiring hospitalization) occur after second infections.<\/li>\n\n\n\n<li>True protection (secondary immunity) develops only after infection with \u22652 serotypes.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Significance of Study<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>EDE-like antibodies could be a biomarker for protective immunity.<\/li>\n\n\n\n<li>Future vaccines may aim to specifically induce high EDE-like antibody levels.<\/li>\n\n\n\n<li>Could improve vaccine safety and cross-serotype protection.<\/li>\n<\/ul>\n\n\n\n<p><strong>Source: <\/strong><a href=\"https:\/\/www.thehindu.com\/sci-tech\/science\/landmark-study-offers-new-insights-into-what-protects-against-dengue\/article69918933.ece#:~:text=The%20study&#039;s%20findings%20illuminated%20the,of%20participants%20having%20detectable%20levels.\" rel=\"nofollow noopener\" target=\"_blank\"><strong>TH<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<h3><strong>Context<\/strong><\/h3>\n<li class=\"ms-5\">A novel study has revealed important insights into developing strong immunity against DENV, which is otherwise quite complex.<\/li>\n<p><\/p>\n<h3><strong>About<\/strong><\/h3>\n<li class=\"ms-5\">Researchers from the US and Philippines have identified specific antibodies, known as envelope dimer epitope (EDE)-like antibodies, as the key for building broad, cross-serotype immunity following natural infection or vaccination.<\/li>\n<li class=\"ms-5\">The findings represent a significant step forward in understanding dengue immunity and could lead to more effective therapeutics.<\/li>\n<p><a href=\"https:\/\/www.nextias.com\/ca\/current-affairs\/12-08-2025\/landmark-study-offers-new-insights-into-what-protects-against-dengue\" class=\"btn btn-primary btn-sm float-end\">Read\u00a0More<\/a><\/p>\n","protected":false},"author":15,"featured_media":51172,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[21],"tags":[],"class_list":["post-51153","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current-affairs"],"acf":[],"jetpack_featured_media_url":"https:\/\/wp-images.nextias.com\/cdn-cgi\/image\/format=auto\/ca\/uploads\/2025\/08\/dengue-protection-insights-study.png","_links":{"self":[{"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/posts\/51153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/comments?post=51153"}],"version-history":[{"count":3,"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/posts\/51153\/revisions"}],"predecessor-version":[{"id":51166,"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/posts\/51153\/revisions\/51166"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/media\/51172"}],"wp:attachment":[{"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/media?parent=51153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/categories?post=51153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nextias.com\/ca\/wp-json\/wp\/v2\/tags?post=51153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}